The authors studied the regulation of cell migration by tuning the spatial stiffness of hydrogels. Migration velocity and cell morphology were analyzed to charaterize the dependence of cell migration on the heterogeneous stiffness in subcellular scale.Publications
Yin et al. (2021) Cell migration regulated by spatially controlled stiffness inside composition-tunable three-dimensional dextran hydrogels. Adv. Mater. Interfaces 8, 2100494 (Link) Applications
Mechanotransduction
Methods
Live/Dead staining (Calcein AM/PI), cell tracking, rheology, atomic force microscopy, scanning electron microscopy of hydrogels, phalloidin staining, immunofluorescence staining, fluorescence imaging
Cells
C2C12 (myoblasts, murine)
Products used
3-D Life Dextran-CD Hydrogel FG
3-D Life RGD Peptide
3-D Life Thioglycerol
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