3-D Life Hydrogel was used to create an extracellular matrix-lumen interface within a microfluidic chip. The successful co-culture of tumor spheroids in the gel and the epithelial cell layer on the gel surface shows the suitability of the setup as a cellular barrier model.Publications
Nair et al. (2021) Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers. Biosensors 11(9), 314 (Article) Applications
Epithelial barrier model, transepithelial cell migration, microfluidics, Microphysiological System (MPS)
Methods
Hydrogel in a microfluidic platform, transepithelial electrical resistance (TEER)
Cells
MDCK (kidney epithelial, canine), HT29 (colon adenocarcinoma, human)
Products used
3-D Life PVA-CD Hydrogel SG
3-D Life RGD Peptide
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