Dextran-based 3-D Life hydrogel modified with RGD peptide was used to grow human proximal tubule cells into spheroids. In these cultures the role of the disintegrin and metalloproteinase ADAM17 was investigated in a fibrotic diabetic milieu. Publications
Palau et al. (2021) Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy. Int. J. Mol. Sci. 22: 5520 (Article) Applications
Kidney fibrosis model
Methods
Immunofluorescence staining, confocal fluorescence microscopy
Cells
HKC-8 (kidney proximal tubular, human)
Products used
3-D Life Dextran-PEG Hydrogel FG
3-D Life RGD Peptide
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