"The 3-D Life PVA-CD Hydrogel suits very well for 3-D cell culture. Not only the gel stiffness can be varied but also the concentration of covalently attached cysteine-containing peptides, such as RGD peptides."
Markus Rimann, Ph.D., ZHAW, Wädenswil, Switzerland

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3-D Life Biomimetic Hydrogels -
Cell Environment Design at Your Fingertips

Cellendes is a life science company offering comprehensive solutions for controlled design of cell environments in 3-D cell culture. A toolbox of reagents provides flexibility in composing biomimetic hydrogels right at the users bench. Areas of application include basic research, drug development and biomedical engineering.

 

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Learn more about the flexible design of 3-D Life Hydrogels

  • Control over cell spreading and migration
  • Independent variation of peptide densities and gel strength
  • Easy recovery of cells after culture
  • Guide to hydrogel compositions for your cell cultures

 

De novo epithelial lumen formation by mammary epithelial cells in 3-D Life Hydrogel:

MCF10A

Mammary epithelial cells (MCF10A) grown for 14 days in 3-D Life Dextran-PEG gel modified with RGD Peptide form epithelia enclosing a lumen (left panel). Lumen formation is impaired when a shRNA specific for the actin nucleator formin-like 2 (FMNL2) is expressed (right panel). Green: F-actin staining. Red: red fluorescent protein indicating activated shRNA transcription. For more information see Grikscheit K, Frank T, Wang Y, Grosse R. (2015). J. Cell Biol. 209:367-76. Figure courtesy of Dr. Katharina Grikscheit, University of Marburg, Germany.

"3-D Life hydrogels were especially suited for long term epithelial cultures with an easy to optimize system and high yield of spheroid formation.", Dr. Katharina Grikscheit, University of Marburg.

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